SWISS-PROT: P41047

ID   FASL_MOUSE     STANDARD;      PRT;   279 AA.
AC   P41047;
DT   01-FEB-1995 (REL. 31, CREATED)
DT   01-FEB-1995 (REL. 31, LAST SEQUENCE UPDATE)
DT   01-OCT-1996 (REL. 34, LAST ANNOTATION UPDATE)
DE   FAS ANTIGEN LIGAND.
GN   FASL.
OS   MUS MUSCULUS (MOUSE).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; MAMMALIA;
OC   EUTHERIA; RODENTIA.
RN   [1]
RP   SEQUENCE FROM N.A.
RX   MEDLINE; 94185175. [MEDLINE, MEDLARS]
RA   TAKAHASHI T., TANAKA M., BRANNAN C.I., JENKINS N.A., COPELAND N.G.,
RA   SUDA T., NAGATA S.;
RL   CELL 76:969-976(1994).
RN   [2]
RP   SEQUENCE FROM N.A., AND 3D-STRUCTURE MODELLING.
RC   STRAIN=C57BL/6;
RX   MEDLINE; 95388076. [MEDLINE, MEDLARS]
RA   PEITSCH M.J., TSCHOPP J.J.;
RL   MOL. IMMUNOL. 32:761-772(1995).
RN   [3]
RP   SEQUENCE FROM N.A.
RX   MEDLINE; 95196085. [MEDLINE, MEDLARS]
RA   LYNCH D.H., WATSON M.L., ALDERSON M.R., BAUM P.R., MILLER R.E.,
RA   TOUGH T., GIBSON M., DAVIS-SMITH T., SMITH C.A., HUNTER K.;
RL   IMMUNITY 1:131-136(1994).
RN   [4]
RP   CHARACTERIZATION OF VARIANT GLD.
RX   MEDLINE; 96091792. [MEDLINE, MEDLARS]
RA   HAHNE M., PEITSCH M.C., IRMLER M., SCHROETER M., LOWIN B.,
RA   ROUSSEAU M., BRON C., RENNO T., FRENCH L., TSCHOPP J.;
RL   INT. IMMUNOL. 7:1381-1386(1995).
CC   -!- FUNCTION: CYTOKINE THAT BINDS TO FAS ANTIGEN, A RECEPTOR THAT
CC       TRANSDUCES THE APOPTOTIC SIGNAL INTO CELLS. MAY BE INVOLVED IN
CC       CYTOTOXYC T CELL MEDIATED APOPTOSIS AND IN T CELL DEVELOPMENT.
CC       FAS-ANTIGEN MEDIATED APOPTOSIS MAY HAVE A ROLE IN THE INDUCTION OF
CC       PERIPHERAL TOLERANCE, IN THE ANTIGEN-STIMULATED SUICIDE OF MATURE
CC       T CELLS, OR BOTH.
CC   -!- SUBUNIT: HOMOTRIMER (PROBABLE).
CC   -!- SUBCELLULAR LOCATION: TYPE II MEMBRANE PROTEIN. MAY BE RELEASED
CC       INTO THE EXTRACELLLULAR FLUID, PROBABLY BY CLEAVAGE FORM THE CELL
CC       SURFACE.
CC   -!- DISEASE: A DEFICIENCY IN THIS PROTEIN IS THE CAUSE OF GENERALIZED
CC       LYMPHOPROLIFERATION DISEASE (GLD), AN AUTOSOMAL RECESSIVE DISEASE
CC       RESPONSIBLE FOR LYMPHADENOPATHY AND AUTOANTIBODY PRODUCTION.
CC   -!- SIMILARITY: BELONGS TO THE TUMOR NECROSIS FACTOR FAMILY.
DR   EMBL; U06948; G473565; -. [EMBL / GenBank / DDBJ]
DR   EMBL; U10984; G511222; -. [EMBL / GenBank / DDBJ]
DR   EMBL; S76752; G913760; -. [EMBL / GenBank / DDBJ]
DR   PROSITE; PS00251; TNF.
DR   PRODOM [Domain structure / List of seq. sharing at least 1 domain]
DR   SWISS-2DPAGE; GET REGION ON 2D PAGE.
KW   CYTOKINE; TRANSMEMBRANE; GLYCOPROTEIN; SIGNAL-ANCHOR; APOPTOSIS;
KW   DISEASE MUTATION.
FT   DOMAIN        1     78       CYTOPLASMIC (POTENTIAL).
FT   TRANSMEM     79    100       SIGNAL-ANCHOR (TYPE-II MEMBRANE PROTEIN).
FT   DOMAIN      100    279       EXTRACELLULAR (POTENTIAL).
FT   DOMAIN        4     69       PRO-RICH.
FT   DOMAIN       45     51       POLY-PRO.
FT   DISULFID    200    231       BY SIMILARITY.
FT   VARIANT     273    273       F -> L (IN GLD; ABOLISH BIDING OF FASL TO
FT                                ITS RECEPTOR).
FT   CARBOHYD    117    117       POTENTIAL.
FT   CARBOHYD    182    182       POTENTIAL.
FT   CARBOHYD    248    248       POTENTIAL.
FT   CARBOHYD    258    258       POTENTIAL.
SQ   SEQUENCE   279 AA;  31442 MW;  AFD84D4B CRC32;
     MQQPMNYPCP QIFWVDSSAT SSWAPPGSVF PCPSCGPRGP DQRRPPPPPP PVSPLPPPSQ
     PLPLPPLTPL KKKDHNTNLW LPVVFFMVLV ALVGMGLGMY QLFHLQKELA ELREFTNQSL
     KVSSFEKQIA NPSTPSEKKE PRSVAHLTGN PHSRSIPLEW EDTYGTALIS GVKYKKGGLV
     INETGLYFVY SKVYFRGQSC NNQPLNHKVY MRNSKYPEDL VLMEEKRLNY CTTGQIWAHS
     SYLGAVFNLT SADHLYVNIS QLSLINFEES KTFFGLYKL
//

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[Model]  Direct Swiss-Model submission

[Image] Direct BLAST submission: at GBRI or at NCBI (Bethesda, USA)

[Image] Sequence analysis tools: ProtParam, ProtScale

[Image]

Manuel C. Peitsch